1. WHAT IS BENFOTIAMINE?
Benfotiamine is a man-made form of thiamine or B1. Thiamine is a water-soluble vitamin and therefore not as easily used by the body. Benfotiamine is a fat-soluble composition and is better absorbed and utilized. There has been some evidence that benfotiamine may help relieve the severity of diabetic complications such as retinopathy, nephropathy and neuropathy. It was developed in Japan in the early 1960's to treat alcoholic neuritis. It is the most effective metabolic precursor of active thiamine, or vitamin B1, available.
2. IS BENFOTIAMINE SAFE
Though benfotiamine is lipid-soluble, it metabolizes quickly, producing high levels of thiamine pyrophosphate (TPP, the active form of thiamine), which then continues to metabolize in the body as usual. Benfotiamine itself does not accumulate in the body. To quote from the European Commission Health and Consumer Protection Directorate General study on the tolerable upper intake level of vitamin B-1, paragraph 3. Hazard Identification:
"3.1. Evidence of adverse effects in humans. Orally ingested vitamin B1 has a long history of use as an oral supplement without reported adverse effects. Due to its therapeutic action in some frequently observed clinical syndromes, thiamine hydrochloride has been advised and used over a long period of time. There are no reports of adverse effects of oral thiamine, even at dosages of several hundred milligrams a day (SCOGS, 1978; DHEW, 1979; Marks, 1989).”
3. HAVE ANY CLINICAL TRIALS BEEN PERFORMED
Yes, here some links to their abstract studies
4. WHAT TYPE OF CONDITIONS MAY RESPOND TO BENFOTIAMINE
Although most of the studies have been in the areas of neuropathy, there has been a good amount of optimism from the studies that may indicate that there are beneficial effects may include general nerve and vascular health, prevention of lactic acidosis, FM, and general health. Read the SUMMARY OF BENFOTIAMINE for more information.
5. IS THERE ANY INTERACTION WITH OTHER MEDICATIONS
Benfotiamine can or may interact with other medications. Thiamine (B-1) may have to be increased or decreased. Please check with your physician or pharmacist for further explanations.
6. WHAT SHOULD BE THE DAILY DOSAGE
It is best to follow the instruction on the bottle. As with all directions start with a smaller amount and build until the desired effect is achieved, but not to exceed the bottle recommendation. One trial used 600mg, http://www.benfotiamine.org/Benfo600Study.pdf
The report on the toxicity of benfotiamine is on this link.
Most people get excellent results in 14-21 days time using two 150mg. capsules twice per day (two in the morning and two in the evening). Benfotiamine need not be taken with meals. The object is to take what is needed but not to excess which simply waste money.
7. IS BENFOTIAMINE A SUPPLEMENT
Benfotiamine is a form of Thiamine (B-1) and is therefore classified as a supplement. Since benfotiamine is classified as a dietary supplement and not a drug, the U.S. FDA has not evaluated its effectiveness. Benfotiamine therefore cannot be represented to diagnose, treat, cure or prevent any disease.
These are testimonials received by the founder of Benfotiamine.org and as such carry only antidotal evidence as to the benefits.
How do I stop the ill effects of AGE? A new class of anti-aging supplements have been shown effective at preventing AGE formation. At this present time, the most effective AGE inhibitors are benfotiamine and pyridoximine. These substances have been proven to stop the formation of Advanced Glycation End-products in the body. Since AGE is more apt to form in the presence of high blood sugar, another important step in AGE prevention is consistent maintenance of normal blood sugar levels through diet, exercise, and supplementation.